Endocrine Abstracts

Diabetes mellitus is characterized by partial or total deficiency of insulin resulting in derangement of carbohydrate metabolism and a decrease in the activity of glycogenic enzymes resulting in depletion of liver and muscle glycogen. Accordingly, this study assessed the influence of OA on two key glycogenic enzymes of skeletal muscle and liver tissues in STZ-induced diabetic rats. We have, however, reported that the anti-hyperglycaemic effects of Syzygium aromaticum de...

We have reported that the anti-hyperglycaemic effects of Syzygium cordatum leaf triterpene mixtures (oleanolic acid (OA) and ursolic acid) in streptozotocin (STZ)-induced diabetic rats are mediated in part via increased hepatic glycogen synthesis. To further elucidate the mechanism(s) of the hypoglycaemic effects of the triterpene, this study investigated the effects of plant derived OA on glycogenic enzyme activities in STZ-induced diabetic rats. Pure OA was obtained f...

The tight glycaemic control in type 1 diabetes which requires uncomfortable multiple insulin injections is associated with patients’ non-compliance. Therefore, methods which can sustain therapeutic controlled insulin release into the blood based on topical applications may be beneficial with glycaemic control. Accordingly, the present study investigated whether topically applied pectin insulin (PI) amidated matrix patch sustains insulin release into the bloodstream and co...